Dr. Siavash K. Kurdistani

Our laboratory investigates the function of chromatin - specifically the roles of histone modifications - in regulation of specific biological processes and their alteration in human disease such as cancer using biochemical, genetic, molecular biological and high-throughput approaches. Presently, we use cancer cell lines, human and murine embryonic stem cells, primary human cancer tissues as well as the model organism, Saccharomyces cerevisiae, to study the basic biology and pathophysiology of histone modifications.